Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Succinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GLI1 | P08151 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL8428394 | 0.94 | NOS2 (0.47) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL998685 | 0.88 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL3987839 | 0.88 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL998686 | 0.88 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL3987842 | 0.88 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL27997258 | 0.86 | NOS2 (0.54) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL27694737 | 0.86 | NOS2 (0.52) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL2939 | 0.85 | — | — | |
| Proline SCHEMBL10141185 | 0.85 | — | — | |
| Proline SCHEMBL462225 | 0.85 | BLM (0.52) | NOS2NOS3NOS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483429-A1 | Biodegradable polymer compositions | NOVA PHARMACEUTICAL CORPORATION (US) | 1992-05-06 | — | — | EP | disclosed |
| US-4999417-A | Drug carriers for controlled release | NOVA PHARMACEUTICAL CORPORATION (US) | 1991-03-12 | — | — | US | disclosed |