Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | ARG1 | P05089 | 2/20 | 0.41 |
| ▸ | PRCP | P42785 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLI1 | P08151 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinamide SCHEMBL9700026 | 0.94 | NOS2 (0.48) | NOS2NOS3NOS1ARG1PRCP | |
| Palmitamide SCHEMBL2983852 | 0.87 | PRCP (0.55) | NOS2NOS3NOS1PRCPMEN1 | |
| Palmitamide SCHEMBL2983849 | 0.87 | PRCP (0.55) | NOS2NOS3NOS1PRCPMEN1 | |
| Proline SCHEMBL3987839 | 0.86 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL998685 | 0.86 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL3987842 | 0.86 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Proline SCHEMBL998686 | 0.86 | NOS2 (0.56) | NOS2NOS3NOS1MEN1KMT2A | |
| Adipic Acid SCHEMBL16915301 | 0.85 | ARG1 (0.41) | NOS2ARG1PRCPMEN1KMT2A | |
| Adipic Acid SCHEMBL16915303 | 0.85 | ARG1 (0.41) | NOS2ARG1PRCPMEN1KMT2A | |
| Glutarate SCHEMBL8628217 | 0.84 | NOS2 (0.39) | NOS2NOS3NOS1ARG1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962660-A | COMPOUND WHICH SUPPRESSES SELECTIN-MEDIATED CELLULAR ADHESION; FOR STABLE ANTIINFLAMMATORY AGENTS WITH BETTER BIOAVAILABILITY AND GREATER ACTIVITY WHICH ARE EASIER TO SYNTHESIZE | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-10-05 | — | — | US | disclosed |
| EP-0815127-A1 | FUCOPEPTIDES | Novartis AG (CH) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996029339-A1 | FUCOPEPTIDES | NOVARTIS AG (CH) | 1996-09-26 | — | — | WO | disclosed |