Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 8/20 | 0.36 |
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
| ▸ | HTR2C | P28335 | 6/20 | 0.36 |
| ▸ | HTR7 | P34969 | 6/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | AQP1 | P29972 | 1/20 | 0.35 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 5/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700535 | 0.81 | HTR2C (0.38) | HTR5AHTR1AHTR2CHTR7HTR1D | |
| SCHEMBL27642723 | 0.81 | CREBBP (0.39) | HTR5AHTR1AHTR2CHTR7HTR1D | |
| SCHEMBL9700331 | 0.81 | MTNR1A (0.40) | HTR1AHTR2CHTR7CYP2D6SLC6A2 | |
| SCHEMBL11854527 | 0.75 | HTR5A (0.43) | HTR5AHTR1AHTR2CHTR7HTR1D | |
| SCHEMBL9699375 | 0.75 | GAA (0.50) | HTR5AHTR1AHTR2CHTR7HTR1D | |
| SCHEMBL9700527 | 0.75 | GAA (0.50) | HTR5AHTR1AHTR2CHTR7SLC6A4 | |
| SCHEMBL9700376 | 0.75 | GAA (0.47) | HTR5AHTR1AHTR2CHTR7CYP2D6 | |
| SCHEMBL9700358 | 0.72 | GAA (0.47) | HTR5AHTR1AHTR2CHTR7GAA | |
| SCHEMBL9700466 | 0.70 | HTR2C (0.31) | HTR2CHTR2A | |
| SCHEMBL9700468 | 0.70 | GAA (0.44) | HTR2CCYP2D6SLC6A2SLC6A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |