Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 2/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699375 | 0.88 | GAA (0.50) | GAACYP2A13KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9700527 | 0.88 | GAA (0.50) | GAAKDM4EALDH1A1SMN1; SMN2HTR5A | |
| SCHEMBL9700376 | 0.85 | GAA (0.47) | GAAHTR5AHTR1AHTR2CHTR7 | |
| SCHEMBL9700468 | 0.82 | GAA (0.44) | GAAMAPTHTR2CMEN1KMT2A | |
| SCHEMBL9701579 | 0.82 | GAA (0.44) | GAAKDM4EALDH1A1SMN1; SMN2HTR1A | |
| SCHEMBL9700535 | 0.76 | HTR2C (0.38) | GAAHTR5AHTR1AHTR2CHTR7 | |
| SCHEMBL27642723 | 0.76 | CREBBP (0.39) | GAAHTR5AHTR1AHTR2CHTR7 | |
| SCHEMBL9700191 | 0.72 | HTR5A (0.36) | GAAHTR5AHTR1AHTR2CHTR7 | |
| SCHEMBL9699340 | 0.72 | CYP2A13 (0.39) | CYP2A13MAPT | |
| SCHEMBL9700277 | 0.70 | GAA (0.47) | GAAALDH1A1HTR1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |