Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217014 | 0.93 | NPC1 (0.36) | NPC1POLBHTTSMN1; SMN2BRD4 | |
| SCHEMBL9195253 | 0.82 | SLC6A3 (0.38) | NPC1POLBHTTSMN1; SMN2MEN1 | |
| SCHEMBL9268721 | 0.80 | NPC1 (0.34) | NPC1POLBHTTSMN1; SMN2NPSR1 | |
| SCHEMBL9701779 | 0.79 | NPC1 (0.34) | NPC1POLBHTTSMN1; SMN2MEN1 | |
| SCHEMBL9740046 | 0.78 | NPC1 (0.37) | NPC1POLBHTTSMN1; SMN2BRD4 | |
| SCHEMBL9700348 | 0.78 | CES1 (0.36) | NPC1POLBHTTSMN1; SMN2MEN1 | |
| SCHEMBL9201756 | 0.76 | NPC1 (0.48) | NPC1POLBHTTSMN1; SMN2MEN1 | |
| SCHEMBL9700477 | 0.76 | GAA (0.42) | NPC1POLBMEN1KMT2ARAB9A | |
| SCHEMBL9268715 | 0.76 | BRD4 (0.35) | NPC1POLBBRD4ATRPARP1 | |
| SCHEMBL9699420 | 0.75 | SLC6A2 (0.40) | NPC1POLBHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992015310-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-17 | — | — | WO | disclosed |