Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 5/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700348 | 0.89 | CES1 (0.36) | NPC1POLBPARP1CES1CHRM5 | |
| SCHEMBL9195253 | 0.89 | SLC6A3 (0.38) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL9699420 | 0.82 | SLC6A2 (0.40) | NPC1POLBCHRM5MEN1KMT2A | |
| SCHEMBL9217152 | 0.81 | CES1 (0.38) | NPC1POLBPARP1CES1CHRM5 | |
| SCHEMBL6362220 | 0.81 | SLC6A3 (0.40) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL6362219 | 0.81 | SLC6A3 (0.40) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL9701475 | 0.80 | MDM2 (0.36) | CHRM5MEN1KMT2AHTTLMNA | |
| SCHEMBL9700390 | 0.79 | NPC1 (0.35) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL9201756 | 0.78 | NPC1 (0.48) | NPC1POLBCHRM5MEN1KMT2A | |
| SCHEMBL9701851 | 0.78 | TSHR (0.37) | NPC1POLBMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992015310-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-17 | — | — | WO | disclosed |