Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | MGAM | O43451 | 4/20 | 0.42 |
| ▸ | SI | P14410 | 4/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216549 | 0.93 | GAA (0.41) | GAAMGAMSIMGAM2HTR1A | |
| SCHEMBL9199100 | 0.82 | PARP1 (0.36) | KDM4ENPC1MAPTPOLBMEN1 | |
| SCHEMBL9195253 | 0.81 | SLC6A3 (0.38) | KDM4ENPC1MAPTPOLBMEN1 | |
| SCHEMBL9201756 | 0.80 | NPC1 (0.48) | KDM4ENPC1MAPTPOLBMEN1 | |
| SCHEMBL9268715 | 0.79 | BRD4 (0.35) | NPC1POLB | |
| SCHEMBL9700348 | 0.79 | CES1 (0.36) | NPC1MAPTPOLBMEN1KMT2A | |
| SCHEMBL9740469 | 0.78 | GAA (0.43) | GAAMGAMSIMGAM2HTR2A | |
| SCHEMBL9701779 | 0.78 | NPC1 (0.34) | NPC1MAPTPOLBMEN1KMT2A | |
| SCHEMBL9700390 | 0.76 | NPC1 (0.35) | NPC1POLBMEN1RAB9AKMT2A | |
| SCHEMBL9203715 | 0.76 | CHRM5 (0.44) | NPC1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992015310-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-17 | — | — | WO | disclosed |