Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30396089 | 1.00 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL1424931 | 0.86 | KDM4E (0.75) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL255577 | 0.79 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL12278703 | 0.79 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL30803985 | 0.79 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL969040 | 0.78 | ALDH1A1 (0.52) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL170969 | 0.78 | KDM4E (1.00) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| Bromide SCHEMBL162182 | 0.78 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL255979 | 0.78 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL174599 | 0.78 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285565-B1 | 2-MERCAPTO-5-PYRIDYL-1,3,4-OXADIAZOLES AND 1,3,4-THIADIAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS NEMATICIDAL AGENTS | CIBA-GEIGY AG (CH) | 1993-09-15 | — | — | EP | claimed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | claimed |
| EP-0285565-A2 | 2-Mercapto-5-pyridyl-1,3,4-oxadiazoles and 1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-10-05 | — | — | EP | claimed |
| CN-110546140-B | Selective HDAC6 inhibitors | 意大发马克股份公司 | 2023-05-16 | — | — | CN | disclosed |
| EP-3562810-B1 | BENZHYDROXAMIC ACID DERIVATIVES AS SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-05-03 | — | — | EP | disclosed |
| EP-3562810-B1 | BENZHYDROXAMIC ACID DERIVATIVES AS SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-05-03 | — | — | EP | disclosed |
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | disclosed |
| US-11351178-B2 | Selective HDAC6 inhibitors | ITALFARMACO SPA (IT) | 2022-06-07 | — | — | US | disclosed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | disclosed |
| US-20210128577-A1 | Selective HDAC6 Inhibitors | ITALFARMACO S.P.A. (IT) | 2021-05-06 | — | — | US | disclosed |
| CN-110546140-A | selective HDAC6 inhibitors | ITALFARMACO SPA | 2019-12-06 | — | — | CN | disclosed |
| EP-0543864-A1 | NOVEL VITAMIN D ANALOGUES. | LEO PHARM PROD LTD (DK) | 1993-06-02 | — | — | EP | disclosed |
| US-5089490-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-18 | — | — | US | disclosed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | disclosed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | disclosed |
| US-4894380-A | NEMATOCIDES | CIBA-GEIGY CORPORATION (US) | 1990-01-16 | — | — | US | disclosed |
| EP-0285565-A2 | 2-Mercapto-5-pyridyl-1,3,4-oxadiazoles and 1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-10-05 | — | — | EP | disclosed |
| EP-0285565-A2 | 2-Mercapto-5-pyridyl-1,3,4-oxadiazoles and 1,3,4-thiadiazoles, process for their preparation and their use as nematicidal agents | CIBA-GEIGY AG (CH) | 1988-10-05 | — | — | EP | disclosed |
| US-4758556-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-07-19 | — | — | US | disclosed |
| US-4278793-A | ANTIBIOTICS, BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210128577-A1 | Selective HDAC6 Inhibitors | HDAC6, HDAC1, HDAC3 | KDM4E 308/4885SMN1; SMN2 1607/4885RAB9A 1377/4885 |
| US-11351178-B2 | Selective HDAC6 inhibitors | HDAC6, HDAC1, HDAC3 | KDM4E 304/4885SMN1; SMN2 1667/4885RAB9A 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.