Sugi Predict

Sugi Predict / Compounds / SCHEMBL170969

SCHEMBL170969

SCHEMBL170969

Nc1nnc(-c2cccnc2)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 7/20 1.00
▸ SMN1; SMN2 Q16637 3/20 1.00
▸ ALDH1A1 P00352 7/20 0.61
▸ HSD17B10 Q99714 3/20 0.61
▸ HPGD P15428 2/20 0.61
▸ RAB9A P51151 4/20 0.55
▸ MEN1 O00255 2/20 0.55
▸ KMT2A Q03164 2/20 0.55
▸ NPC1 O15118 2/20 0.55
▸ CYP2A6 P11509 3/20 0.53
▸ CYP3A4 P08684 2/20 0.53
▸ CYP2E1 P05181 1/20 0.53
▸ CYP2D6 P10635 1/20 0.53
▸ CYP2C9 P11712 1/20 0.53
▸ CYP2B6 P20813 1/20 0.53
▸ CYP2C19 P33261 1/20 0.53
▸ MGAM O43451 3/20 0.50
▸ GAA P10253 3/20 0.50
▸ SI P14410 3/20 0.50
▸ MGAM2 Q2M2H8 3/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30494594 1.00 KDM4E (1.00) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL1424931 0.86 KDM4E (0.75) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL12278703 0.79 KDM4E (0.66) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL30803985 0.79 KDM4E (0.66) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL255577 0.79 KDM4E (0.66) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL1208217 0.78 KDM4E (0.64) KDM4ESMN1; SMN2ALDH1A1HSD17B10RAB9A
SCHEMBL45441 0.78 KDM4E (0.67) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL255979 0.78 KDM4E (0.64) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL970073 0.78 KDM4E (0.64) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD
SCHEMBL174599 0.78 KDM4E (0.64) KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083724-A1 COMPOUNDS TARGETING PAX3::FOXO1 FUSION PROTEIN GEORGETOWN UNIVERSITY (US) 2026-03-26 — — US disclosed
US-20240270735-A1 CDK19-Selective Inhibitors, and Methods of Use Thereof CHAN ZUCKERBERG BIOHUB, INC. 2024-08-15 — — US disclosed
CN-112279845-B Aryl or heteroaryl substituted thiadiazoles compounds and antibacterial application thereof 中国医学科学院药物研究所 2023-07-28 — — CN disclosed
US-20230158025-A1 GALACTOKINASE INHIBITORS NATIONAL INSTITUTES OF HEALTH 2023-05-25 — — US disclosed
WO-2021216812-A1 GALACTOKINASE INHIBITORS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2021-10-28 — — WO disclosed
CN-112279845-A Aryl or heteroaryl substituted thiadiazole compounds and antibacterial application thereof 中国医学科学院药物研究所 2021-01-29 — — CN disclosed
US-20170107212-A1 NOVEL COMPOUNDS Bayer Pharma AG (DE) 2017-04-20 — — US disclosed
CN-106458983-A Novel compound 拜耳制药股份公司 2017-02-22 — — CN disclosed
EP-3119759-A1 NOVEL COMPOUNDS Bayer Pharma Aktiengesellschaft (DE) 2017-01-25 — — EP disclosed
CN-103188936-B Insecticidal composition DOW AGROSCIENCES LLC (US) 2016-04-20 — — CN disclosed
CN-101691662-B Carbon steel pickling corrosion inhibitor and preparation method and application thereof NANJING UNIVERSITY OF TECHNOLOGY 2011-01-12 — — CN disclosed
CN-101691662-B Carbon steel pickling corrosion inhibitor and preparation method and application thereof NANJING UNIVERSITY OF TECHNOLOGY 2011-01-12 — — CN disclosed
CN-101691662-A Carbon steel pickling corrosion inhibitor and preparation method and application thereof NANJING UNIVERSITY OF TECHNOLOGY 2010-04-07 — — CN disclosed
CN-101691662-A Carbon steel pickling corrosion inhibitor and preparation method and application thereof NANJING UNIVERSITY OF TECHNOLOGY 2010-04-07 — — CN disclosed
EP-1054876-A1 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS PHARMACIA & UPJOHN S.p.A. (IT) 2000-11-29 — — EP disclosed
WO-1999028309-A1 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1999-06-10 — — WO disclosed
EP-0159707-B1 TRIAZOLOPYRIMIDINE DERIVATIVES DAIICHI SEIYAKU CO., LTD. (JP) 1990-01-24 — — EP disclosed
US-4652646-A ANTIALLERGENS DAIICHI SEIYAKU CO., LTD. (JP) 1987-03-24 — — US disclosed
EP-0159707-A2 Triazolopyrimidine derivatives DAIICHI SEIYAKU CO., LTD. (JP) 1985-10-30 — — EP disclosed
US-4522944-A ANTIINFLAMMATORY AGENTS AND PAIN KILLERS FARMITALIA CARLO ERBA S.P.A., MILAN ITALY A CORP OF ITALY (IT) 1985-06-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240270735-A1 CDK19-Selective Inhibitors, and Methods of Use Thereof CDK19, CDK9, CDK1 KDM4E 904/4885SMN1; SMN2 3193/4885ALDH1A1 4629/4885
US-20170107212-A1 NOVEL COMPOUNDS WNT1, CTNNB1, WNT3A KDM4E 3482/4885SMN1; SMN2 2586/4885ALDH1A1 2281/4885
US-20230158025-A1 GALACTOKINASE INHIBITORS GALK1, GCK, GCKR KDM4E 2218/4885SMN1; SMN2 3570/4885ALDH1A1 3139/4885
US-20260083724-A1 COMPOUNDS TARGETING PAX3::FOXO1 FUSION PROTEIN PAX3, FOXO1, PAXBP1 KDM4E 680/4885SMN1; SMN2 48/4885ALDH1A1 2739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.