Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 20/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | FPR1 | P21462 | 1/20 | 0.46 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9282153 | 0.88 | CYP4F2 (0.40) | FFAR1FFAR4CHRM2S1PR1FPR1 | |
| SCHEMBL9743368 | 0.85 | FFAR1 (0.36) | FFAR1 | |
| SCHEMBL9743363 | 0.80 | RARB (0.35) | FFAR1 | |
| SCHEMBL9843036 | 0.80 | FFAR1 (0.32) | FFAR1 | |
| SCHEMBL9180592 | 0.80 | RARA (0.46) | — | |
| SCHEMBL8877092 | 0.78 | CYP3A4 (0.33) | — | |
| SCHEMBL8875083 | 0.77 | CYP26A1 (0.38) | FFAR1FFAR4 | |
| SCHEMBL9843090 | 0.77 | EPHX2 (0.36) | — | |
| SCHEMBL9550154 | 0.76 | GABRP (0.35) | — | |
| SCHEMBL8877011 | 0.76 | FFAR1 (0.34) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992006084-A1 | CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY | ALLERGAN, INC. (US) | 1992-04-16 | — | — | WO | disclosed |
| EP-0419131-A2 | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN, INC. (US) | 1991-03-27 | — | — | EP | disclosed |