SCHEMBL9700776

SCHEMBL9700776

CC(CI)N(C(=O)c1cc(Br)c(OCCCCCOc2ccc(C=NN)cc2)c(Br)c1)C(C)CI

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 2/20 0.37
LTB4R2 Q9NPC1 1/20 0.36
KLK1 P06870 1/20 0.36
GAA P10253 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
HDAC3 O15379 1/20 0.33
STAT3 P40763 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
GPR119 Q8TDV5 1/20 0.33
LSS P48449 1/20 0.32
THRA P10827 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9700781 0.90 LTB4R (0.36) LTB4RLTB4R2GAAL3MBTL1GPR119
SCHEMBL8994934 0.88 LTB4R (0.43) LTB4RLTB4R2KLK1HDAC3STAT3
Hydrochloric Acid SCHEMBL9701746 0.87 GAA (0.43) LTB4RLTB4R2GAAL3MBTL1GPR119
Hydrochloric Acid SCHEMBL9700974 0.87 LTB4R (0.46) LTB4RLTB4R2GAAL3MBTL1HDAC3
SCHEMBL9699613 0.81 LTB4R (0.59) LTB4RLTB4R2L3MBTL1THRATHRB
Hydrochloric Acid SCHEMBL9700654 0.81 THRB (0.40) LTB4RLTB4R2GAATHRATHRB
Hydrochloric Acid SCHEMBL9701722 0.81 LTB4R (0.58) LTB4RLTB4R2L3MBTL1THRATHRB
SCHEMBL9119999 0.81 LTB4R (0.46) LTB4RLTB4R2GAAHDAC3STAT3
Hydrochloric Acid SCHEMBL9701749 0.80 THRA (0.39) LTB4RLTB4R2GAAL3MBTL1GPR119
Hydrochloric Acid SCHEMBL8994939 0.80 LTB4R (0.45) LTB4RLTB4R2GAAHDAC3STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0518819-A2 Amidino compounds, their manufacture and use as medicament CIBA-GEIGY AG (CH) 1992-12-16 EP disclosed