Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ADH5 | P11766 | 5/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699755 | 0.81 | NR2E1 (0.36) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9700837 | 0.78 | PDE3B (0.43) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL9700740 | 0.77 | PDE3B (0.64) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL9700822 | 0.73 | CYP11B1 (0.42) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL9700774 | 0.72 | ALDH1A1 (0.32) | — | |
| SCHEMBL9699776 | 0.72 | PDE3B (0.38) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL14280506 | 0.67 | KCNH2 (0.33) | CYP11B1CYP11B2 | |
| SCHEMBL9700819 | 0.65 | CYP11B1 (0.41) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL9740131 | 0.64 | PDE3B (0.57) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL16673120 | 0.63 | CYP3A4 (0.62) | CYP11B1CYP11B2ADH5IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171851-A | Cardiac stimulant | DONG-A PHARM. CO., LTD. (KR) | 1992-12-15 | — | — | US | claimed |
| EP-0510235-A1 | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same | DONG-A PHARM. CO., LTD. (KR) | 1992-10-28 | — | — | EP | claimed |
| US-5171851-A | Cardiac stimulant | DONG-A PHARM. CO., LTD. (KR) | 1992-12-15 | — | — | US | disclosed |
| EP-0510235-A1 | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same | DONG-A PHARM. CO., LTD. (KR) | 1992-10-28 | — | — | EP | disclosed |