Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.51 |
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30615772 | 0.91 | PNMT (0.56) | LMNASLC2A1ADRB3ADRB1ADRB2 | |
| SCHEMBL25518189 | 0.91 | PNMT (0.56) | LMNASLC2A1ADRB3ADRB1ADRB2 | |
| SCHEMBL14830680 | 0.89 | SLC2A1 (0.57) | SLC2A1ADRB3ADRB1ADRB2ADRA1D | |
| SCHEMBL25517567 | 0.89 | LMNA (0.65) | LMNAADRB3ACP3KMT2APNMT | |
| SCHEMBL8305207 | 0.82 | SLC2A1 (0.81) | SLC2A1ADRB3ADRB1ADRB2ADRA1D | |
| SCHEMBL7150600 | 0.82 | SLC2A1 (0.81) | SLC2A1ADRB3ADRB1ADRB2ADRA1D | |
| SCHEMBL7150601 | 0.82 | SLC2A1 (0.81) | SLC2A1ADRB3ADRB1ADRB2ADRA1D | |
| SCHEMBL27673218 | 0.81 | SLC6A2 (0.49) | LMNASLC2A1ACP3MEN1KMT2A | |
| SCHEMBL7487581 | 0.80 | LMNA (0.81) | LMNAADRB3ADRB1ADRB2MEN1 | |
| SCHEMBL7486711 | 0.80 | LMNA (0.81) | LMNAADRB3ADRB1ADRB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440706-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-14 | — | — | US | disclosed |
| US-8372873-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-12 | — | — | US | disclosed |
| WO-1992006076-A1 | SEMICARBAZONE ARTHROPODICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-04-16 | — | — | WO | disclosed |