SCHEMBL9701629

SCHEMBL9701629

Nc1ccc(Cc2ccc(N)c(Cl)c2Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.50
ALDH1A1 P00352 3/20 0.50
TSHR P16473 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
GFER P55789 1/20 0.39
HTR6 P50406 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.38
CYP17A1 P05093 1/20 0.37
CYP19A1 P11511 1/20 0.37
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
MAOA P21397 2/20 0.34
MAOB P27338 2/20 0.34
MAPT P10636 2/20 0.34
HRH3 Q9Y5N1 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL48329 0.83 CYP3A4 (0.39) CYP3A4ALDH1A1TSHRTDP1MEN1
SCHEMBL29987755 0.83 CYP3A4 (0.39) CYP3A4ALDH1A1TSHRTDP1MEN1
SCHEMBL11228666 0.77 CYP3A4 (0.44) CYP3A4ALDH1A1TSHRTDP1MEN1
SCHEMBL1042000 0.74 PNMT (0.55) CYP3A4ALDH1A1TSHRTDP1GFER
SCHEMBL990234 0.73 CYP3A4 (0.52) CYP3A4ALDH1A1TSHRTDP1GFER
SCHEMBL31175762 0.73 CYP3A4 (0.52) CYP3A4ALDH1A1TSHRTDP1GFER
SCHEMBL11678565 0.73 CYP3A4 (0.38) CYP3A4ALDH1A1TSHRTDP1CA1
SCHEMBL9318804 0.72 CYP3A4 (0.56) CYP3A4ALDH1A1TSHRTDP1GFER
SCHEMBL23501533 0.72 CYP3A4 (0.56) CYP3A4ALDH1A1TSHRTDP1GFER
SCHEMBL8765756 0.72 CYP3A4 (0.56) CYP3A4ALDH1A1TSHRTDP1GFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5106943-A Molding materials; blend of trimer of polyisocyanate, epoxy compounds, and aromatic polyamine TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-04-21 US disclosed
EP-0421393-A2 Resin, compositions, shaped articles, and methods for manufacture Takeda Chemical Industries, Ltd. (JP) 1991-04-10 EP disclosed