Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213340 | 0.87 | NPC1 (0.36) | TSHRCYP3A4NFKB1THPOHIF1A | |
| SCHEMBL9195253 | 0.83 | SLC6A3 (0.38) | TSHRMAPTLMNAHTTALDH1A1 | |
| SCHEMBL9700566 | 0.80 | HSD11B1 (0.36) | TSHRMAPTLMNAHTTALDH1A1 | |
| SCHEMBL9268721 | 0.79 | NPC1 (0.34) | CA12CA9HTTSMN1; SMN2ALOX15 | |
| SCHEMBL9701779 | 0.78 | NPC1 (0.34) | MAPTLMNACYP1A2HTTSMN1; SMN2 | |
| SCHEMBL9739485 | 0.78 | CYP1A2 (0.37) | TSHRCYP3A4NFKB1THPOHIF1A | |
| SCHEMBL9700348 | 0.77 | CES1 (0.36) | TSHRMAPTLMNACYP1A2HTT | |
| SCHEMBL9700610 | 0.76 | RXFP1 (0.40) | TSHRCYP3A4MAPTLMNACYP1A2 | |
| SCHEMBL6362219 | 0.76 | SLC6A3 (0.40) | TSHRMAPTLMNAHTTALDH1A1 | |
| SCHEMBL6362220 | 0.76 | SLC6A3 (0.40) | TSHRMAPTLMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992015310-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-17 | — | — | WO | disclosed |