Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5674033 | 0.80 | NOTUM (0.67) | NOTUMSCN2AMAP2K1IDO1KDM4E | |
| SCHEMBL11204644 | 0.79 | MEN1 (0.58) | NOTUMMAP2K1KDM4EGAAHTT | |
| SCHEMBL1384813 | 0.77 | NOTUM (1.00) | NOTUMMAP2K1KDM4EALDH1A1LMNA | |
| SCHEMBL25078457 | 0.77 | NOTUM (0.62) | NOTUMMAP2K1KDM4EALDH1A1LMNA | |
| SCHEMBL7368040 | 0.77 | NOTUM (0.62) | NOTUMMAP2K1IDO1ALDH1A1GAA | |
| SCHEMBL8986949 | 0.75 | NOTUM (0.50) | NOTUMBRD4SCN2APGRKDM4E | |
| SCHEMBL237434 | 0.74 | IDO1 (0.56) | NOTUMBRD4SCN2AIDO1KDM4E | |
| SCHEMBL8535240 | 0.73 | NOTUM (0.68) | NOTUMMAP2K1KDM4EALDH1A1 | |
| SCHEMBL5210215 | 0.73 | BRD4 (0.53) | NOTUMBRD4SCN2AIDO1PGR | |
| SCHEMBL24732324 | 0.73 | NOTUM (0.56) | NOTUMMAP2K1IDO1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |