Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 3/20 | 0.46 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.39 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701825 | 0.79 | NOTUM (0.62) | HTTKDM4EGAANOTUMMAP2K1 | |
| SCHEMBL5674033 | 0.79 | NOTUM (0.67) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL9536366 | 0.74 | NOTUM (0.60) | NOTUMMAP2K1 | |
| SCHEMBL8987030 | 0.73 | HTT (0.47) | MEN1HTTKMT2AKDM4EUSP2 | |
| SCHEMBL8535240 | 0.72 | NOTUM (0.68) | KDM4ENOTUMMAP2K1NPY5RCYP1B1 | |
| SCHEMBL25078457 | 0.72 | NOTUM (0.62) | MEN1KMT2AKDM4EMAPTNOTUM | |
| SCHEMBL7368040 | 0.72 | NOTUM (0.62) | GAAALOX12NOTUMMAP2K1TYMP | |
| SCHEMBL1384813 | 0.71 | NOTUM (1.00) | HTTKDM4EGAAMAPTNOTUM | |
| SCHEMBL9227395 | 0.71 | AHR (0.52) | MEN1HTTKMT2AKDM4EUSP2 | |
| SCHEMBL7369068 | 0.71 | NOTUM (0.67) | MEN1KMT2AUSP2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0090353-A1 | 2-Pyridone derivatives, method for their preparation and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-10-05 | — | — | EP | disclosed |