Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | BLM | P54132 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | THRB | P10828 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | AGER | Q15109 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.58 |
| ▸ | PLEC | Q15149 | 1/20 | 0.58 |
| ▸ | APAF1 | O14727 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9702743 | 0.89 | INSR (0.67) | MAPTGAAMEN1BLMKMT2A | |
| SCHEMBL9702101 | 0.84 | MAPT (0.57) | MAPTGAAMEN1BLMKMT2A | |
| SCHEMBL6795311 | 0.82 | MAPT (0.80) | MAPTGAAMEN1BLMKMT2A | |
| SCHEMBL10055010 | 0.82 | MAPT (0.80) | MAPTGAAMEN1BLMKMT2A | |
| SCHEMBL11511077 | 0.79 | HIF1A (0.67) | MAPTGAAMEN1BLMKMT2A | |
| SCHEMBL13219246 | 0.77 | CYP1A2 (0.45) | ALOX15MAPK1HSD17B10PKMTDP1 | |
| SCHEMBL4670284 | 0.77 | ALOX5 (0.46) | MAPTALOX15HSD17B10KDM4ETDP1 | |
| SCHEMBL22773430 | 0.76 | MAPT (0.71) | MAPTGAAMEN1BLMKMT2A | |
| SCHEMBL10184604 | 0.76 | MEN1 (0.60) | MAPTGAAMEN1BLMKMT2A | |
| Bromide SCHEMBL27590510 | 0.76 | ALOX5 (0.45) | MAPTALOX15HSD17B10KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |