SCHEMBL9702140

SCHEMBL9702140

Cc1nccn1-c1ccc(N)c(CO)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADH5 P11766 3/20 0.48
CYP3A4 P08684 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP19A1 P11511 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP2E1 P05181 1/20 0.43
CYP2A6 P11509 1/20 0.43
HTR1A P08908 1/20 0.43
HTR2C P28335 1/20 0.43
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
PDE4A P27815 3/20 0.40
PDE4B Q07343 3/20 0.40
PDE4C Q08493 3/20 0.40
PDE4D Q08499 3/20 0.40
PDE3B Q13370 2/20 0.38
PDE3A Q14432 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1830492 0.87 ADH5 (0.46) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL8696264 0.82 CYP3A4 (0.47) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL7404600 0.81 ALDH1A1 (0.51) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL8694716 0.79 ADH5 (0.44) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL8694730 0.79 CYP3A4 (0.44) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL8694865 0.77 CYP3A4 (0.46) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL8694727 0.77 CYP3A4 (0.43) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL3830592 0.77 ALDH1A1 (0.47) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL9700828 0.77 ALDH1A1 (0.50) ADH5CYP3A4CYP1A2CYP2D6CYP19A1
SCHEMBL10900003 0.76 ALDH1A1 (0.50) ADH5CYP3A4CYP1A2CYP2D6CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5171851-A Cardiac stimulant DONG-A PHARM. CO., LTD. (KR) 1992-12-15 US disclosed
EP-0510235-A1 Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same DONG-A PHARM. CO., LTD. (KR) 1992-10-28 EP disclosed