Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | ADH5 | P11766 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696264 | 0.82 | CYP3A4 (0.47) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL10902395 | 0.82 | ICMT (0.53) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL1912040 | 0.81 | CYP3A4 (0.48) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8694730 | 0.80 | CYP3A4 (0.44) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8694716 | 0.80 | ADH5 (0.44) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL5381277 | 0.78 | ICMT (0.47) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8694727 | 0.78 | CYP3A4 (0.43) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL9702140 | 0.77 | ADH5 (0.48) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL10902066 | 0.75 | TUBB4A (0.49) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL10903913 | 0.74 | TUBB4A (0.52) | CYP3A4CYP1A2CYP2D6CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753682-A | Imidazole lipoxygenase inhibitors | PFIZER INC. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0703913-B1 | IMIDAZOLES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0703913-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029299-A1 | IMIDAZOLE LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-12-22 | — | — | WO | disclosed |