SCHEMBL9702369

SCHEMBL9702369

O=S(=O)(O)c1ccc(CC(F)C(F)C(F)F)cc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.41
ALDH1A1 P00352 3/20 0.39
TSHR P16473 2/20 0.39
NT5E P21589 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
TDP1 Q9NUW8 1/20 0.36
POLB P06746 1/20 0.34
CYP2D6 P10635 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
MMP2 P08253 4/20 0.33
MMP9 P14780 3/20 0.33
ADAMTS4 O75173 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL776506 0.81 LMNA (0.46) LMNAALDH1A1TSHRNT5ESMN1; SMN2
SCHEMBL775989 0.78 LMNA (0.43) LMNAALDH1A1TSHRNT5ESMN1; SMN2
SCHEMBL9243139 0.74 TDP1 (0.47) LMNAALDH1A1TSHRNT5ESMN1; SMN2
SCHEMBL6266176 0.73 ALDH1A1 (0.58) LMNAALDH1A1TSHRSMN1; SMN2MEN1
SCHEMBL29029870 0.73 LMNA (0.46) LMNAALDH1A1TSHRNT5ESMN1; SMN2
SCHEMBL9697268 0.72 LMNA (0.38) LMNAALDH1A1TSHRNT5ESMN1; SMN2
SCHEMBL29285318 0.70 TAAR1 (0.57)
SCHEMBL9568574 0.70 LMNA (0.43) LMNAALDH1A1TSHRNT5ESMN1; SMN2
SCHEMBL19457401 0.70 LMNA (0.43) LMNAALDH1A1TSHRNT5ESMN1; SMN2
SCHEMBL9921556 0.70 LMNA (0.52) LMNAALDH1A1TSHRNT5ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992011400-A1 AZEOTROPE-LIKE COMPOSITIONS OF DICHLOROPENTAFLUOROPROPANE, AN ALKANOL HAVING 1-3 CARBON ATOMS AND 2-METHYL-2-PROPANOL ALLIED-SIGNAL INC. (US) 1992-07-09 WO disclosed