Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 6/20 | 0.37 |
| ▸ | METAP1 | P53582 | 4/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSH | P09668 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968622 | 0.90 | REN (0.31) | REN | |
| SCHEMBL499254 | 0.87 | CTSK (0.36) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL3607292 | 0.87 | CTSK (0.36) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL499255 | 0.87 | CTSK (0.36) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL3607293 | 0.87 | CTSK (0.36) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL1866462 | 0.85 | CTSK (0.34) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL1866461 | 0.85 | CTSK (0.34) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL1859646 | 0.81 | SLC6A2 (0.34) | METAP2 | |
| SCHEMBL1863285 | 0.81 | SLC6A2 (0.34) | METAP2 | |
| SCHEMBL1862797 | 0.80 | ANPEP (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872028-B2 | Diaminopropanol renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2011-01-18 | — | — | US | disclosed |