Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28641016 | 0.86 | MAPT (0.73) | MAPTLMNAKDM4ENPC1RAB9A | |
| SCHEMBL9702101 | 0.85 | MAPT (0.57) | MAPTLMNAKDM4ENPC1TP53 | |
| SCHEMBL13451639 | 0.82 | PPARG (0.63) | MAPTLMNAKDM4ENPC1CYP1A2 | |
| SCHEMBL6687730 | 0.78 | MAPT (0.86) | MAPTLMNAKDM4ENPC1CYP1A2 | |
| SCHEMBL9667596 | 0.77 | CHRM2 (0.67) | MAPTLMNAKDM4ENPC1TP53 | |
| SCHEMBL5517703 | 0.76 | CHRM2 (0.66) | MAPTKDM4ENPC1RAB9APPARG | |
| Nabumetone SCHEMBL5915038 | 0.76 | MAPT (0.71) | MAPTLMNAKDM4ENPC1TP53 | |
| SCHEMBL1581217 | 0.75 | MAPT (0.72) | MAPTLMNAKDM4ESMN1; SMN2GAA | |
| Bromide SCHEMBL11279741 | 0.75 | L3MBTL1 (0.51) | MAPTCYP1A2ESR1ESR2HCAR2 | |
| SCHEMBL27973336 | 0.75 | LTA4H (0.54) | MAPTNPC1TP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |