Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.30 |
| ▸ | GRM6 | O15303 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GSR | P00390 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.30 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL9839515 | 1.00 | SLC1A5 (0.35) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| Serine SCHEMBL18191257 | 0.91 | SLC1A5 (0.41) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| Serine SCHEMBL3517747 | 0.91 | SLC1A5 (0.41) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| Serine SCHEMBL9702742 | 0.91 | SLC1A5 (0.41) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| SCHEMBL10521761 | 0.91 | NOS3 (0.39) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| Serine SCHEMBL7925097 | 0.87 | SLC1A5 (0.42) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| Serine SCHEMBL15094110 | 0.86 | SLC1A5 (0.38) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| Serine SCHEMBL3821533 | 0.86 | SLC1A5 (0.38) | SLC1A5NOS3NOS1NOS2SLC1A1 | |
| Serine SCHEMBL9222362 | 0.86 | SLC1A1 (0.41) | NOS2SLC1A1GRM8GRM6GRIN2D | |
| Glycine SCHEMBL8588130 | 0.84 | GLRA1 (0.42) | SLC1A5NOS3NOS1NOS2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0328634-A4 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PSORIASIS | — | 1991-08-21 | — | — | EP | claimed |
| EP-0328634-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PSORIASIS | DEXTER CHEMICAL CORPORATION (US) | 1989-08-23 | — | — | EP | claimed |
| WO-1989001930-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PSORIASIS | DEXTER BIOTECHNICS (US) | 1989-03-09 | — | — | WO | claimed |