Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703323 | 0.84 | CDK4 (0.47) | AMY1APDE3BPDE3APDE5A | |
| SCHEMBL9704539 | 0.82 | AMY1A (0.40) | AMY1APDE3BPDE3APDE5ANPC1 | |
| SCHEMBL9704521 | 0.82 | CDK4 (0.42) | AMY1APDE3BPDE3APDE5ATP53 | |
| SCHEMBL10700314 | 0.77 | AMY1A (0.48) | AMY1APDE3BPDE3ANPC1RAB9A | |
| SCHEMBL10551871 | 0.76 | AMY1A (0.40) | AMY1APDE3BPDE3APDE5ANPC1 | |
| SCHEMBL10849719 | 0.76 | AMY1A (0.41) | AMY1AMAPK1PDE3BPDE3APDE5A | |
| SCHEMBL9379210 | 0.75 | NPC1 (0.55) | MAPK1PDE3BPDE3ANPC1RAB9A | |
| SCHEMBL10373868 | 0.73 | PDE3B (0.49) | AMY1APDE3BPDE3APDE5ANPC1 | |
| SCHEMBL10678386 | 0.73 | PDE5A (0.49) | AMY1APDE3BPDE3APDE5ANPC1 | |
| SCHEMBL10848272 | 0.73 | PDE2A (0.40) | MAPK1PDE3BPDE3APDE5ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |