Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | DRD4 | P21917 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703158 | 0.83 | DRD2 (0.81) | DRD2DRD4DRD3MAPT | |
| SCHEMBL9703331 | 0.81 | DRD2 (1.00) | DRD2DRD4DRD3 | |
| SCHEMBL18324709 | 0.74 | KDM4E (0.72) | DRD2ALDH1A1KDM4EPOLBBRD4 | |
| SCHEMBL9703358 | 0.74 | KDM4E (0.56) | ALDH1A1KDM4EPOLBBRD4CREBBP | |
| SCHEMBL8307180 | 0.74 | GFER (0.67) | ALDH1A1KDM4EHSD17B10CYP2C9HPGD | |
| SCHEMBL9703250 | 0.73 | DRD2 (0.79) | DRD2DRD4DRD3ALDH1A1HSD17B10 | |
| SCHEMBL8474192 | 0.72 | KDM4E (0.70) | ALDH1A1KDM4EHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL5052466 | 0.71 | KDM4E (0.72) | ALDH1A1KDM4EHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL25404953 | 0.71 | KDM4E (0.63) | ALDH1A1KDM4EHSD17B10HPGDHTT | |
| SCHEMBL9703912 | 0.71 | DRD2 (0.79) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |