Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.79 |
| ▸ | DRD3 | P35462 | 4/20 | 0.79 |
| ▸ | DRD4 | P21917 | 2/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703912 | 0.89 | DRD2 (0.79) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL9703331 | 0.89 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL9703684 | 0.87 | DRD2 (0.75) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9703158 | 0.79 | DRD2 (0.81) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9703330 | 0.79 | DRD2 (0.81) | DRD2DRD3DRD4CYP2D6 | |
| SCHEMBL19823060 | 0.75 | DRD2 (0.66) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL9703913 | 0.73 | DRD2 (0.66) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL9703731 | 0.73 | DRD2 (0.68) | DRD2DRD3DRD4CYP1A2CYP3A4 | |
| SCHEMBL9773160 | 0.72 | DRD2 (0.70) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL3849926 | 0.72 | DRD2 (0.70) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | claimed |
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |