Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.43 |
| ▸ | BRD4 | O60885 | 7/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9704675 | 0.87 | CES1 (0.39) | CREBBPBRD4ARPGREP300 | |
| SCHEMBL6589819 | 0.79 | AR (0.48) | ARPGR | |
| SCHEMBL11724231 | 0.76 | ACHE (0.47) | CREBBPBRD4ARPGREP300 | |
| SCHEMBL10914586 | 0.74 | CES1 (0.42) | CREBBPBRD4CYP2C9EP300IDO1 | |
| SCHEMBL3025028 | 0.71 | ALPL (0.33) | PGRLMNAHSD17B10IDO1 | |
| SCHEMBL11715697 | 0.71 | KDM4E (0.50) | CREBBPBRD4 | |
| SCHEMBL22868112 | 0.70 | ACHE (0.46) | CREBBPBRD4EP300LMNA | |
| SCHEMBL20288981 | 0.69 | PBRM1 (0.51) | CREBBPBRD4AREP300LMNA | |
| SCHEMBL9803709 | 0.69 | MEN1 (0.51) | HTR2AHTR2CHTR2BUSP2LMNA | |
| SCHEMBL12156816 | 0.69 | AR (0.44) | CREBBPBRD4ARPGREP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203795-B1 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4720495-A | Benzo[ij]quinolizine-2-carboxylic acids useful for treating bacterial infection | TOKYO TANABE CO. LIMITED (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0203795-A2 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1986-12-03 | — | — | EP | disclosed |