Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL866939 | 0.88 | NPC1 (0.60) | EGFRERBB2MAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL9703883 | 0.85 | MAPT (0.63) | MAOBALOX5ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11714868 | 0.81 | MEN1 (0.67) | EGFRERBB2MAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL2636983 | 0.80 | PPARA (0.60) | MAOBALOX5ALDH1A1MAPTGAA | |
| SCHEMBL28900204 | 0.79 | RAB9A (0.71) | ALDH1A1SMN1; SMN2MAPTGAANPC1 | |
| SCHEMBL30022351 | 0.79 | RAB9A (0.71) | ALDH1A1SMN1; SMN2MAPTGAANPC1 | |
| SCHEMBL10833896 | 0.79 | CTSV (0.69) | ALDH1A1SMN1; SMN2MAPTALOX12GAA | |
| SCHEMBL8737849 | 0.79 | AR (0.65) | EGFRERBB2MAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL10937794 | 0.78 | SIRT2 (0.61) | EGFRERBB2MAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL791985 | 0.78 | MAOB (0.69) | MAOBSMN1; SMN2MAPTGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4910208-A | Skin disorders, antiinflammatory agent | E. R. SQUIBB & SONS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4814454-A | ANTIALLERGENS, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |