SCHEMBL9703895

SCHEMBL9703895

CON=C(C(=O)O)c1nc(C(=O)OC(C)(C)C)sc1N

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GRM6 O15303 1/20 0.34
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27340438 0.81 GRM6 (0.38) GRM6
SCHEMBL4686476 0.81 GRM6 (0.40) GRM6LMNAGAAMAPT
SCHEMBL27754067 0.76 GRM6 (0.36) GRM6
SCHEMBL11264947 0.76 GRM6 (0.35) GRM6
Hydrochloric Acid SCHEMBL11273202 0.75 GRM6 (0.34) GRM6
SCHEMBL9446743 0.73 GRM6 (0.33) GRM6
SCHEMBL27363484 0.73 GRM6 (0.33) GRM6
SCHEMBL27703537 0.73 ALDH1A1 (0.49) LMNAGAAMAPT
SCHEMBL11124083 0.73 LMNA (0.35) LMNAGAAMAPT
SCHEMBL27638360 0.71 GRM6 (0.41) GRM6GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0494733-A1 Trifluoromethyl 1-carba(1-dethia)cephems ELI LILLY AND COMPANY (US) 1992-07-15 EP disclosed