Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.31 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705120 | 0.90 | POLB (0.43) | POLBHTR1ATDP1P2RX4LIPE | |
| SCHEMBL9705236 | 0.81 | MEN1 (0.33) | KMT2ASMN1; SMN2MAPT | |
| SCHEMBL9704457 | 0.78 | HTT (0.30) | P2RX4HTTP2RX1P2RX3P2RX7 | |
| SCHEMBL9704716 | 0.77 | P2RX1 (0.36) | POLBHTR1AP2RX4ALDH1A1P2RX1 | |
| SCHEMBL11587574 | 0.67 | ALDH1A1 (0.50) | POLBHTR1AP2RX4LIPEALDH1A1 | |
| SCHEMBL7171235 | 0.66 | ALDH1A1 (0.42) | POLBHTTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL12928358 | 0.64 | HTR1A (0.69) | POLBHTR1ATDP1HTTALDH1A1 | |
| SCHEMBL22350718 | 0.64 | HTR1A (0.69) | POLBHTR1ATDP1HTTALDH1A1 | |
| SCHEMBL4612540 | 0.63 | HTR1A (0.62) | POLBHTR1ATDP1P2RX4HTT | |
| SCHEMBL1858027 | 0.62 | HTR1A (0.67) | POLBHTR1ATDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |