Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703781 | 0.90 | ADRB2 (0.46) | POLBADRB2HPGDALDH1A1STAT3 | |
| SCHEMBL9705531 | 0.85 | HPGD (0.38) | BAZ2BBAZ2APOLBADRB2HPGD | |
| SCHEMBL9703806 | 0.85 | KMT2A (0.43) | BAZ2BBAZ2APOLBHPGDALDH1A1 | |
| SCHEMBL9703818 | 0.85 | KDM4E (0.48) | POLBHPGDALDH1A1LMNAKMT2A | |
| SCHEMBL9704661 | 0.84 | DYRK1A (0.39) | BAZ2BBAZ2APOLBADRB2HPGD | |
| SCHEMBL9704598 | 0.83 | STAT3 (0.50) | ADRB2HPGDALDH1A1STAT3KMT2A | |
| SCHEMBL9703286 | 0.82 | HPGD (0.44) | BAZ2BBAZ2APOLBADRB2HPGD | |
| SCHEMBL10646921 | 0.82 | MAOB (0.34) | BAZ2BBAZ2APOLBADRB2ALDH1A1 | |
| SCHEMBL9703378 | 0.79 | ADRB2 (0.45) | BAZ2BBAZ2APOLBADRB2HPGD | |
| SCHEMBL11720415 | 0.78 | KDM4E (0.47) | ADRB2HPGDALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203795-B1 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4720495-A | Benzo[ij]quinolizine-2-carboxylic acids useful for treating bacterial infection | TOKYO TANABE CO. LIMITED (JP) | 1988-01-19 | — | — | US | disclosed |
| EP-0203795-A2 | Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same | TOKYO TANABE COMPANY LIMITED (JP) | 1986-12-03 | — | — | EP | disclosed |