Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.39 |
| ▸ | MERTK | Q12866 | 4/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | POLA1 | P09884 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9704728 | 0.82 | PDE4A (0.43) | PAK1CDK4CCND1CCND2CCND3 | |
| SCHEMBL9704936 | 0.77 | POLA1 (0.41) | FLT3TYRO3MERTKGAS6AXL | |
| SCHEMBL9705994 | 0.72 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL15264150 | 0.70 | PAK1 (1.00) | PAK1LMNAADORA3CDK2CDK1 | |
| SCHEMBL9705260 | 0.69 | NOS1 (0.45) | — | |
| SCHEMBL9706008 | 0.69 | NOS3 (0.40) | — | |
| SCHEMBL15545184 | 0.68 | PAK1 (0.97) | PAK1LMNAADORA3CDK2POLA1 | |
| SCHEMBL18786068 | 0.67 | PI4KA (0.44) | — | |
| SCHEMBL7851163 | 0.67 | PI4KA (0.49) | — | |
| SCHEMBL30523392 | 0.66 | PAK1 (0.91) | PAK1LMNAADORA3CDK2POLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |