Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027058 | 0.79 | AOC3 (0.44) | SLC6A4SLC6A3 | |
| SCHEMBL20284764 | 0.77 | DRD2 (0.43) | DRD2HTR2ADRD3HTR1A | |
| SCHEMBL1856022 | 0.75 | CYP2A6 (0.44) | DRD2HTR2ADRD3CYP2D6SLC6A2 | |
| SCHEMBL28550307 | 0.74 | AOC3 (0.42) | SLC6A4SLC6A3 | |
| SCHEMBL2599485 | 0.72 | CYP2D6 (0.65) | DRD2DRD3HTR1ACYP2D6SLC6A2 | |
| SCHEMBL7385487 | 0.72 | PARP1 (0.41) | — | |
| SCHEMBL27403589 | 0.72 | CYP2D6 (0.65) | DRD2DRD3HTR1ACYP2D6SLC6A2 | |
| SCHEMBL27471535 | 0.71 | HRH1 (0.47) | DRD2DRD3HTR1ACYP2D6KCNH2 | |
| SCHEMBL2467564 | 0.71 | HTR2A (0.49) | DRD2HTR2ADRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL2599502 | 0.71 | CYP2D6 (0.63) | DRD2DRD3HTR1ACYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230179-B1 | 4-MORPHOLINYL 1H-INDOLE DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES OF PREPARATION, USE AS THERAPEUTIC AGENTS, COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-09-30 | — | — | EP | disclosed |