Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703005 | 0.85 | MEN1 (0.46) | ESR1ESR2CYP1A2NPC1RAB9A | |
| SCHEMBL7153902 | 0.84 | ESR1 (0.47) | ESR1ESR2NPC1RAB9AMEN1 | |
| SCHEMBL25969111 | 0.81 | CYP1A2 (0.43) | ESR1ESR2CYP1A2ESRRGNPC1 | |
| SCHEMBL1176872 | 0.79 | ESR1 (0.49) | ESR1ESR2CYP1A2NPC1RAB9A | |
| SCHEMBL3975700 | 0.77 | NPSR1 (0.52) | ESR1ESR2NPC1RAB9AMEN1 | |
| SCHEMBL2038478 | 0.76 | ESR1 (0.46) | ESR1ESR2CYP1A2NPC1RAB9A | |
| SCHEMBL25969113 | 0.76 | ESR1 (0.42) | ESR1ESR2CYP1A2NPC1RAB9A | |
| SCHEMBL712464 | 0.75 | ESR1 (0.42) | ESR1ESR2CYP1A2ESRRGNPC1 | |
| SCHEMBL28269013 | 0.72 | TSHR (0.56) | ESR1ESR2CYP1A2NPC1MEN1 | |
| SCHEMBL1680160 | 0.72 | CYP1A2 (0.54) | ESR1ESR2CYP1A2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4910208-A | Skin disorders, antiinflammatory agent | E. R. SQUIBB & SONS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4814454-A | ANTIALLERGENS, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |