Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.48 |
| ▸ | NOS1 | P29475 | 3/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16739648 | 0.84 | HTT (0.41) | NOS3NOS1NOS2MAPTPKM | |
| SCHEMBL9851464 | 0.83 | NOS3 (0.49) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL21533570 | 0.79 | NOS1 (0.47) | NOS3NOS1NOS2MAPTPKM | |
| SCHEMBL21533568 | 0.78 | NOS3 (0.44) | NOS3NOS1NOS2MAPTPKM | |
| SCHEMBL9704690 | 0.76 | PI4KA (0.43) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL7388204 | 0.75 | NOS3 (0.43) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL7851163 | 0.75 | PI4KA (0.49) | NOS3NOS1NOS2PI4KAPI4K2B | |
| SCHEMBL8805356 | 0.74 | MAPT (0.79) | MAPTPKMKDM4EMEN1KMT2A | |
| SCHEMBL9203040 | 0.73 | SMN1; SMN2 (0.49) | NOS3NOS1NOS2KDM4EL3MBTL1 | |
| SCHEMBL8326986 | 0.72 | NOS1 (0.54) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |