SCHEMBL9705589

SCHEMBL9705589

BrCc1ccc(OCCOc2ccc(CBr)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.43
ALDH1A1 P00352 1/20 0.43
TSHR P16473 1/20 0.43
HRH3 Q9Y5N1 3/20 0.42
LTA4H P09960 2/20 0.42
PRSS1 P07477 1/20 0.41
CHKA P35790 1/20 0.41
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HTT P42858 1/20 0.40
KCNA3 P22001 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1573293 0.93 APP (0.47) TRPA1ALDH1A1TSHR
SCHEMBL9539720 0.93 APP (0.47) TRPA1ALDH1A1TSHR
SCHEMBL9705573 0.92 KCNA3 (0.50) HRH3PRSS1KCNA3
SCHEMBL9539656 0.90 KCNA3 (0.48) KCNA3
SCHEMBL10614694 0.90 KCNA3 (0.48) KCNA3
SCHEMBL4086993 0.90 TRPA1 (0.40) TRPA1ALDH1A1TSHRHRH3LTA4H
SCHEMBL9705568 0.90 KCNA3 (0.48) KCNA3
SCHEMBL9829763 0.89 ACACB (0.42) HRH3KEAP1NFE2L2
SCHEMBL18179721 0.87 PPARA (0.43) HRH3
SCHEMBL4105829 0.86 APP (0.56) ALDH1A1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116178258-A N-methylaniline quinoline compound and synthetic method and application thereof 中国医学科学院北京协和医院 2023-05-30 CN claimed
EP-0228803-A2 Ionene elastomers MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1987-07-15 EP claimed
CN-116178258-B N-methylaniline quinoline compound and synthetic method and application thereof 中国医学科学院北京协和医院 2023-11-21 CN disclosed
CN-116178258-A N-methylaniline quinoline compound and synthetic method and application thereof 中国医学科学院北京协和医院 2023-05-30 CN disclosed
WO-2015185780-A1 SYMMETRICAL POLAR INHIBITORS OF CHOLINE KINASE WITH ANTI-TUMOUR ACTIVITY UNIVERSIDAD DE GRANADA (ES) 2015-12-10 WO disclosed
EP-0228803-B1 IONENE ELASTOMERS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-09-16 EP disclosed