SCHEMBL9705669

SCHEMBL9705669

COC(=O)c1cc(Cl)c(OCCCCCc2cc(C)no2)c(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.41
NR1I2 O75469 1/20 0.41
CYP3A4 P08684 1/20 0.41
HDAC6 Q9UBN7 3/20 0.39
MRGPRX4 Q96LA9 1/20 0.38
VHL P40337 1/20 0.36
KDM4E B2RXH2 3/20 0.36
MAPT P10636 1/20 0.36
PLAU P00749 2/20 0.36
ALDH1A1 P00352 4/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9705738 0.93 KDM4E (0.41) CYP2D6NR1I2CYP3A4HDAC6MRGPRX4
SCHEMBL9705709 0.89 MAPT (0.40) CYP2D6NR1I2CYP3A4HDAC6KDM4E
SCHEMBL9200429 0.88 PLAU (0.49) CYP2D6NR1I2CYP3A4HDAC6MRGPRX4
SCHEMBL9436198 0.87 LMNA (0.42) CYP2D6NR1I2CYP3A4HDAC6VHL
SCHEMBL10413619 0.85 NR1I2 (0.44) CYP2D6NR1I2CYP3A4HDAC6KDM4E
SCHEMBL9705981 0.85 HDAC6 (0.41) CYP2D6NR1I2CYP3A4HDAC6VHL
SCHEMBL9201652 0.85 NR1I2 (0.39) CYP2D6NR1I2CYP3A4HDAC6VHL
SCHEMBL9705732 0.85 HDAC6 (0.41) CYP2D6NR1I2CYP3A4HDAC6MAPT
SCHEMBL9862957 0.84 CYP3A4 (0.44) CYP2D6NR1I2CYP3A4VHLKDM4E
SCHEMBL8875953 0.83 NR1I2 (0.55) CYP2D6NR1I2CYP3A4HDAC6VHL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0207454-B1 ISOXAZOLE AND FURAN DERIVATIVES, THEIR PREPARATION AND USE AS ANTIVIRAL AGENTS STERLING WINTHROP INC. (US) 1992-09-09 EP disclosed
US-5002960-A Viricides for combating picornaviruses STERLING DRUG, INC. (US) 1991-03-26 US disclosed
US-4939267-A Viricides STERLING DRUG INC. (US) 1990-07-03 US disclosed
US-4843087-A OXAZOLINYL COMPOUNDS; RHINOVIRUSES AND PICORNAVIRUSES STERLING DRUG INC. (US) 1989-06-27 US disclosed
EP-0207454-A2 Isoxazole and furan derivatives, their preparation and use as antiviral agents STERLING WINTHROP INC. (US) 1987-01-07 EP disclosed