SCHEMBL9706646

SCHEMBL9706646

Cn1c(CF)c(F)c(=O)n(-c2cc(C(=O)O)c(Cl)cc2F)c1=O

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 9/20 0.37
GRM4 Q14833 2/20 0.34
MYC P01106 1/20 0.33
NR4A1 P22736 1/20 0.33
CTSB P07858 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
BRD9 Q9H8M2 1/20 0.32
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MAPT P10636 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9706643 0.85 LMNA (0.35) ALDH1A1HPGDSMN1; SMN2MAPT
SCHEMBL9706512 0.84 NOTUM (0.41) NOTUMGRM4MYCNR4A1CTSB
SCHEMBL9706650 0.83 NOTUM (0.34) NOTUMGRM4MYCNR4A1CTSB
SCHEMBL9706664 0.81 GRM4 (0.36) NOTUMGRM4MYCNR4A1CTSB
SCHEMBL24151268 0.81 NOTUM (0.38) NOTUMMYCNR4A1CTSBTDP1
SCHEMBL29938165 0.81 NOTUM (0.38) NOTUMMYCNR4A1CTSBTDP1
SCHEMBL9706662 0.81 NOTUM (0.40) NOTUMGRM4MYCNR4A1CTSB
SCHEMBL9706659 0.80 NOTUM (0.39) NOTUMGRM4MYCNR4A1CTSB
SCHEMBL9706621 0.78 NOTUM (0.36) NOTUMGRM4MYCNR4A1CTSB
SCHEMBL9706626 0.78 NOTUM (0.36) NOTUMGRM4MYCNR4A1CTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0195346-B1 3-ARYL URACILES AND THEIR USE AS HERBICIDES CIBA-GEIGY AG (CH) 1992-06-24 EP claimed