SCHEMBL9706673

SCHEMBL9706673

O=C(O)c1cc(-n2c(=O)[nH]c3c(c2=O)CCC3)c(F)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.40
TSHR P16473 1/20 0.37
LMNA P02545 3/20 0.36
MAPT P10636 2/20 0.36
ALDH1A1 P00352 5/20 0.34
HSD17B10 Q99714 2/20 0.34
KDM4E B2RXH2 1/20 0.34
POLB P06746 3/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
MAPK1 P28482 2/20 0.33
EPHX2 P34913 1/20 0.33
ALOX15 P16050 1/20 0.33
GFER P55789 1/20 0.33
TTR P02766 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
BLM P54132 1/20 0.32
CTDSP1 Q9GZU7 1/20 0.32
CSNK2A2 P19784 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9706536 0.98 HPGD (0.38) HPGDTSHRLMNAMAPTALDH1A1
SCHEMBL9706696 0.86 HPGD (0.38) HPGDTSHRLMNAMAPTALDH1A1
SCHEMBL9706578 0.84 TSHR (0.34) HPGDTSHRLMNAMAPTALDH1A1
SCHEMBL9706630 0.83 EPHX2 (0.31) LMNAALDH1A1MEN1KMT2AEPHX2
SCHEMBL9706613 0.82 PPOX (0.36) HPGDTSHRLMNAMAPTALDH1A1
SCHEMBL9706593 0.79 TDP1 (0.48) HPGDTSHRLMNAMAPTALDH1A1
SCHEMBL10575094 0.78 PPOX (0.50) HPGDTSHRLMNAMAPTALDH1A1
SCHEMBL9706663 0.77 NOTUM (0.40) HPGDTSHRALDH1A1HSD17B10KDM4E
SCHEMBL9706705 0.77 NOTUM (0.37) HPGDTSHRHSD17B10KDM4ETTR
SCHEMBL9706674 0.77 TDP1 (0.48) HPGDTSHRLMNAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0195346-B1 3-ARYL URACILES AND THEIR USE AS HERBICIDES CIBA-GEIGY AG (CH) 1992-06-24 EP claimed