SCHEMBL9706812

SCHEMBL9706812

COc1ccc(COC(=O)c2ccccc2CC([NH])=O)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
MMP9 P14780 2/20 0.48
MMP1 P03956 1/20 0.48
MMP2 P08253 1/20 0.47
MMP12 P39900 1/20 0.47
USP2 O75604 1/20 0.47
TP53 P04637 1/20 0.47
TDP1 Q9NUW8 3/20 0.46
CYP3A4 P08684 1/20 0.46
TSHR P16473 1/20 0.46
MAPK1 P28482 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ATM Q13315 1/20 0.43
FABP7 O15540 1/20 0.43
FABP5 Q01469 1/20 0.43
P2RX4 Q99571 1/20 0.43
DHODH Q02127 2/20 0.43
HTT P42858 1/20 0.43
CASP3 P42574 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22283425 0.79 TDP1 (0.71) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL29024631 0.78 RAB9A (0.63) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL4683771 0.78 FFAR1 (0.46) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL4680610 0.76 CYP3A4 (0.48) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL14066485 0.74 CYP3A4 (0.46) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL7285341 0.74 ALDH1A1 (0.65) ALDH1A1TDP1CYP3A4TSHRMAPK1
SCHEMBL2842512 0.74 KMT2A (0.71) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL1565585 0.73 ALDH1A1 (0.57) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL20710413 0.73 MMP9 (0.47) ALDH1A1MMP9MMP1MMP2MMP12
SCHEMBL3649876 0.73 HTT (0.63) ALDH1A1USP2TP53TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0222022-B1 PROCESS FOR PRODUCING BETA-LACTAM DERIVATIVES Otsuka Kagaku Kabushiki Kaisha (JP) 1992-09-23 EP disclosed
US-5070194-A DEPROTECTION OF INTERMEDIATES OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1991-12-03 US disclosed