Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814010 | 0.89 | ACE (0.49) | ACENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9707078 | 0.82 | ACE (0.49) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9707085 | 0.80 | SMN1; SMN2 (0.68) | NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9707098 | 0.79 | ACE (0.43) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11547220 | 0.77 | NPC1 (0.59) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11548414 | 0.76 | ACE (0.52) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9510615 | 0.75 | SMN1; SMN2 (0.53) | NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9814008 | 0.75 | SMN1; SMN2 (0.70) | NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11544959 | 0.74 | DPP4 (0.49) | ACECHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL9513854 | 0.74 | SMN1; SMN2 (0.52) | NPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190685-B1 | HETEROCYCLIC AMIDES | G.D. Searle & Co. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4981853-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0190685-A2 | Heterocyclic amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |