Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.97 |
| ▸ | RAB9A | P51151 | 10/20 | 0.97 |
| ▸ | NPC1 | O15118 | 10/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.97 |
| ▸ | HPGD | P15428 | 5/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18719831 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL3457093 | 0.84 | RAB9A (1.00) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL12503286 | 0.83 | FKBP1A (0.71) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL24815875 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL29986809 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL9707085 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL18928678 | 0.79 | NPC1 (0.62) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL25087867 | 0.76 | SMN1; SMN2 (0.84) | SMN1; SMN2RAB9ANPC1ALDH1A1USP2 | |
| SCHEMBL1540452 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL1540451 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252474-B1 | HYDRAZINE DERIVATIVES | AMERICAN CYANAMID COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |
| EP-0525832-A1 | Substituted 1,2,3- thiadiazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1993-02-03 | — | — | EP | disclosed |
| US-4916237-A | Substituted 1,2,3-thiadiazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| US-4803280-A | Substituted 1,2,3-thia-diazole-4-thiolates | AMERICAN CYANAMID COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0252474-A2 | Hydrazine derivatives | AMERICAN CYANAMID COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |