Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.39 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707790 | 0.93 | AGTR1 (0.38) | AGTR1AGTR2PPARG | |
| SCHEMBL9707463 | 0.89 | KMT2A (0.45) | AGTR1AGTR2GPR18PPARGKMT2A | |
| SCHEMBL9707747 | 0.82 | KDM4E (0.44) | AGTR1AGTR2GPR18 | |
| SCHEMBL9708115 | 0.81 | KMT2A (0.42) | AGTR1AGTR2PPARGKMT2A | |
| SCHEMBL9707407 | 0.81 | GPR18 (0.39) | AGTR1AGTR2GPR18PPARG | |
| SCHEMBL9709026 | 0.81 | KMT2A (0.43) | AGTR1AGTR2GPR18KMT2A | |
| SCHEMBL9708761 | 0.81 | ADORA3 (0.43) | AGTR1AGTR2PPARGKMT2A | |
| SCHEMBL9708395 | 0.81 | KMT2A (0.42) | AGTR1AGTR2PPARGKMT2A | |
| SCHEMBL9707844 | 0.81 | AGTR1 (0.45) | AGTR1AGTR2GPR18 | |
| SCHEMBL9707302 | 0.80 | GPR18 (0.38) | AGTR1AGTR2GPR18PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | claimed |
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |