Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1436622 | 0.88 | ALOX5 (0.70) | PTGS1ALOX5PTGS2LMNATSHR | |
| SCHEMBL9707452 | 0.87 | ALOX5 (0.86) | PTGS1ALOX5PTGS2HTTFFAR1 | |
| Cyclohexane SCHEMBL9835197 | 0.83 | ALOX5 (0.64) | PTGS1ALOX5PTGS2LMNATSHR | |
| SCHEMBL9707420 | 0.81 | ALOX5 (0.70) | PTGS1ALOX5PTGS2FFAR1 | |
| SCHEMBL9876964 | 0.81 | TAAR1 (0.50) | PTGS1ALOX5PTGS2TAAR1ABCC4 | |
| SCHEMBL9707541 | 0.81 | RIPK1 (0.59) | PTGS1ALOX5PTGS2TAAR1ABCC4 | |
| SCHEMBL11177458 | 0.80 | TAAR1 (0.53) | PTGS1ALOX5PTGS2TAAR1ABCC4 | |
| SCHEMBL9707287 | 0.79 | ALOX5 (0.52) | PTGS1ALOX5PTGS2 | |
| SCHEMBL9877530 | 0.77 | NPC1 (0.48) | PTGS1ALOX5TAAR1ABCC4LMNA | |
| SCHEMBL9707326 | 0.77 | ALOX5 (0.57) | PTGS1ALOX5PTGS2LMNARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196184-B1 | ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-09-16 | — | — | EP | disclosed |
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |