Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707266 | 0.86 | ALOX5 (0.61) | ALOX5PTGS1PTGS2FFAR1ALOX5AP | |
| SCHEMBL1436622 | 0.84 | ALOX5 (0.70) | ALOX5PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL24217539 | 0.83 | MEN1 (0.59) | NR3C1FFAR1SRD5A2LTA4HMEN1 | |
| SCHEMBL9707249 | 0.83 | ALOX5 (1.00) | ALOX5PTGS1PTGS2FFAR1 | |
| SCHEMBL9707239 | 0.81 | PTGS2 (0.59) | ALOX5PTGS1PTGS2LTA4H | |
| SCHEMBL9707312 | 0.81 | PTGS1 (0.62) | ALOX5PTGS1PTGS2FFAR1 | |
| SCHEMBL9707452 | 0.79 | ALOX5 (0.86) | ALOX5PTGS1PTGS2FFAR1PTGES | |
| Cyclohexane SCHEMBL9835197 | 0.79 | ALOX5 (0.64) | ALOX5PTGS1PTGS2MEN1KMT2A | |
| SCHEMBL10612279 | 0.78 | LTA4H (0.61) | NR3C1FFAR1SRD5A2LTA4HPTGES | |
| SCHEMBL850542 | 0.75 | SRD5A2 (0.62) | NR3C1FFAR1SRD5A2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196184-B1 | ARYL DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-09-16 | — | — | EP | disclosed |
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |