Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.46 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 8/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.46 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9708923 | 0.95 | TRPC4 (0.47) | TRPC4TRPC5KCNH2AGTR1AGTR2 | |
| SCHEMBL9708070 | 0.94 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL9707808 | 0.93 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9707950 | 0.92 | AGTR1 (0.48) | AGTR1AGTR2USP2ALDH1A1NPSR1 | |
| SCHEMBL9707515 | 0.92 | AGTR1 (0.50) | AGTR1AGTR2 | |
| SCHEMBL9708644 | 0.91 | ALDH1A1 (0.50) | AGTR1AGTR2USP2ALDH1A1NPSR1 | |
| SCHEMBL9708699 | 0.91 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9707530 | 0.91 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL9707462 | 0.90 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9708599 | 0.90 | AGTR1 (0.50) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | claimed |
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |