Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CPN1 | P15169 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23042508 | 0.97 | EPHX1 (0.41) | EPHX1ALDH1A1CYP2C9CYP2C19HIF1A | |
| SCHEMBL29013509 | 0.92 | — | — | |
| SCHEMBL11797010 | 0.87 | — | — | |
| SCHEMBL5275955 | 0.82 | EPHX1 (0.46) | EPHX1ALDH1A1DPP4ATMNPC1 | |
| SCHEMBL9754311 | 0.80 | EPHX1 (0.44) | EPHX1ALDH1A1DPP4ATMNPC1 | |
| SCHEMBL27991206 | 0.78 | EPHX1 (0.60) | EPHX1ALDH1A1DPP4ATMSMN1; SMN2 | |
| SCHEMBL7865468 | 0.76 | ALDH1A1 (0.39) | EPHX1ALDH1A1KDM4ELMNACPN1 | |
| SCHEMBL11373290 | 0.76 | CES2 (0.44) | EPHX1ALDH1A1DPP4ATMNPC1 | |
| SCHEMBL23042507 | 0.75 | EPHX1 (0.56) | EPHX1ALDH1A1DPP4TP53 | |
| SCHEMBL27851647 | 0.75 | EPHX1 (0.40) | EPHX1ALDH1A1CYP2C9CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030555-B1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2019-01-30 | — | — | EP | disclosed |
| EP-3030555-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2016-06-15 | — | — | EP | disclosed |
| US-9096548-B2 | Pyrazine amide compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-08-04 | — | — | US | disclosed |
| US-20150045326-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-12 | — | — | US | disclosed |
| WO-2015018754-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-12 | — | — | WO | disclosed |
| EP-0220034-B1 | MALONATE DERIVATIVES USEFUL AS LIGHT STABILIZERS FOR PLASTICS | ICI AMERICAS INC. (US) | 1992-06-24 | — | — | EP | disclosed |
| US-4851461-A | PHOTOSTABILIZERS | ICI AMERICAS INC. (US) | 1989-07-25 | — | — | US | disclosed |
| US-4804699-A | Monomeric and oligomeric glutarate-based light stabilizers for plastics | ICI AMERICAS INC. (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0291238-A2 | Monomeric and oligomeric glutarate-based light stabilisers for plastics | ICI AMERICAS INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4710527-A | STERICALLY HINDERED SPIROACETALS OF POLYALKYLPIPERIDIN-4-ONES | ICI AMERICAS INC. (US) | 1987-12-01 | — | — | US | disclosed |
| US-4701485-A | Malonate-based light stabilizers for plastics | ICI AMERICAS INC. (US) | 1987-10-20 | — | — | US | disclosed |
| US-4689360-A | SPIRO RING CONTAINING ESTERS | ICI AMERICAS INC. (US) | 1987-08-25 | — | — | US | disclosed |
| EP-0222512-A2 | Malonate compounds useful as light stabilizers for plastics | CYTEC TECHNOLOGY CORP. (US) | 1987-05-20 | — | — | EP | disclosed |
| EP-0220034-A2 | Malonate derivatives useful as light stabilizers for plastics | ICI AMERICAS INC. (US) | 1987-04-29 | — | — | EP | disclosed |
| EP-0219333-A2 | Oligomeric malonates, useful as light stabilizers for plastics | ICI AMERICAS INC. (US) | 1987-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045326-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | HRH4, HRH1, HRH2 | EPHX1 2899/4885ALDH1A1 1861/4885CYP2C9 1406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.