Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.30 |
| ▸ | CPA1 | P15085 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051932 | 0.81 | CA2 (0.65) | CA1CA2ALDH1A1TDP1ZDHHC7 | |
| SCHEMBL11331406 | 0.81 | ALDH1A1 (0.49) | CA1CA2ALDH1A1LMNAMEN1 | |
| SCHEMBL5879370 | 0.80 | CA2 (0.58) | CA1CA2ALDH1A1LMNAGRIK1 | |
| SCHEMBL2137726 | 0.80 | ALDH1A1 (0.51) | CA1CA2ALDH1A1LMNAMEN1 | |
| SCHEMBL28087826 | 0.80 | CA2 (0.62) | CA1CA2ALDH1A1TDP1ZDHHC7 | |
| SCHEMBL5677958 | 0.80 | GRIK1 (0.46) | CA2ALDH1A1MEN1KMT2AGRIK1 | |
| SCHEMBL5599531 | 0.79 | CA2 (0.56) | CA1CA2ALDH1A1LMNAGRIK1 | |
| SCHEMBL9732859 | 0.79 | LMNA (0.54) | CA1CA2ALDH1A1LMNAKMT2A | |
| SCHEMBL7165372 | 0.79 | CA2 (0.56) | CA1CA2ALDH1A1LMNAGRIK1 | |
| SCHEMBL9709918 | 0.79 | CA1 (0.43) | CA1CA2ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0493324-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |