Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 11/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 11/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709617 | 1.00 | AGTR1 (0.36) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709855 | 0.88 | ACP1 (0.42) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709845 | 0.88 | ACP1 (0.42) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709866 | 0.87 | AGTR1 (0.47) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709813 | 0.86 | AGTR1 (0.38) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709808 | 0.86 | AGTR1 (0.38) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709589 | 0.85 | AGTR1 (0.49) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709803 | 0.83 | AGTR1 (0.41) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709738 | 0.83 | AGTR1 (0.37) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709905 | 0.82 | USP1 (0.40) | AGTR1AGTR2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | claimed |